Inhibiting Systemic Autophagy during Interleukin 2 Immunotherapy Promotes Long-term Tumor Regression
نویسندگان
چکیده
منابع مشابه
Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression.
Administration of high-dose interleukin-2 (HDIL-2) has durable antitumor effects in 5% to 10% of patients with melanoma and renal cell carcinoma. However, treatment is often limited by side effects, including reversible, multiorgan dysfunction characterized by a cytokine-induced systemic autophagic syndrome. Here, we hypothesized that the autophagy inhibitor chloroquine would enhance IL-2 immun...
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Administration of high-dose interleukin-2 (HDIL-2) has durable antitumor effects in 5% to 10% of patients with melanoma and renal cell carcinoma. However, treatment is often limited by side effects, including reversible, multiorgan dysfunction characterized by a cytokine-induced systemic autophagic syndrome. Here, we hypothesized that the autophagy inhibitor chloroquine would enhance IL-2 immun...
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1Department of Surgery, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh PA, 15213 2Center for Biologic Imaging, University of Pittsburgh 3Department of Immunology 4UPCI Molecular and Cellular Biology Program. University of Pittsburgh Running Title: Inhibition of IL-2 Induced Autophagy Prolongs Survival Precis: The preclinical study shows how the inexpensive autophagy i...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2012
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-12-0320